Established in 1902, Cebu Normal University became a state college in 1976 and attained university status in 1998. Located in Cebu City, CNU has two other campuses in the province of Cebu: Medellin and Balamban.

Silliman University, established in 1901, is a leading Christian university situated in Dumaguete City, Negros Oriental. It offers programs from basic education to post-graduate studies.

One of the six constituents of the UP System, the University of the Philippines Visayas (UPV) has three campuses in the Visayas Region. The main campus is located in Miagao, Iloilo, while the other two are based in Iloilo City and Tacloban City in Leyte.

AdZU began as a parochial school called Escuela Catolica and was managed by the Spanish Jesuit congregation in 1912. It was renamed Ateneo de Zamboanga in 1916 and became a university in 2001. AdZU has programs from grade school to post-graduate studies.

AdDU is a premier Catholic university founded by the Philippine Province of the Society of Jesus in 1948. It has programs from basic education to post-graduate studies.

Located in Palo, Leyte, the School of Health Sciences was created in the mid-1970s. Its step-ladder curriculum was approved in 1976. The step-ladder curriculum is in three parts: obtaining a midwifery certificate, a nursing degree, and a medical degree. It was established as a response to growing concerns that students are lacking in social consciousness and commitment to community service.

The Tuguegarao City-based St. Paul University Philippines was founded in 1907. In 1982, it became both the first university and first Catholic university in Cagayan Valley.

Davao Medical School Foundation was established in 1976 to answer the need for doctors in rural areas. It is operated by a consortium comprised of members from Ateneo de Davao University, Brokenshire Memorial Hospital, Development of People’s Foundation, San Pedro Hospital, and San Pedro College.